Neuroinflammation and Disruption of the Gut-blood-brain Barriers--Benefits of Natural Flavonoids
Autistic children often present with auto-antibodies against brain proteins, gastrointestinal problems, "allergies" and fatigue, implying a neuro-imunoendocrine problem. Mast cells serve an "sensors" of environmental cell damage and respond the brain/gut peptide neurotensin by secreting mitochondrial (mt)DNA, which diverts energy from brain growth and induces an inflammatory state. The natural flavonoids quercetin and luteolin (found in the supplement NeuroProtek) can block these processes.
Theoharis C. Theoharides, MS, PhD, MD,
He is Director of Molecular Immunopharmacology & Drug Discovery Lab, Professor of Pharmacology, Biochemistry and Internal Medicine at Tufts U. He trained at Yale U and has over 290 publications. He showed that mast cells secrete inflammatory mediators that disrupt the gut-blood-brain barriers, thus playing a critical role in brain inflammation and autism. Dr. Theoharides extends his expertise beyond theory into practical options for patients with diseases that have defied treatment to date.
