Immune Dysregulation in Autism - CME Program
The immune system is intricately involved in brain development and its functional regulation. The brain’s intrinsic immune system modulates synaptic communication, and is equally important to defense from free radical damage and excitotoxicity. The GALT is 70% of the peripheral immune system and complex dysregulation of the gut immune system is well documented in a distinct autism subgroup. Additional evidence supports autoimmunity in pathogenesis of autism. This autoimmune process appears to overlap with streptococcal related cross-reactivity with basal ganglia (PANDAS). Autoantibodies are also noted to interfere with cerebral folate metabolism. These immunological aberrations will be defined. Appropriate diagnostic testing will be discussed with the intent of aiding the clinician in the workup and treatment.
James Jeffrey Bradstreet, MD, MD(H), F
Dr. Bradstreet obtained his medical degree from the University of South Florida and his residency training at Wilford Hall USAF Medical Center. He is extensively published on the subjects of immunology, toxicology and molecular biology. Currently he is enhancing techniques for stem cell yield from adipose tissue. This work continues and enhances his efforts at immunotherapy, heavy metal detoxfication and restoration of a healthy gut ecosystem.
