Is There an Intervention That Combines Antioxidant, Anti-inflammatory, Metal Chelating, Mitochondrial-protective, and Neuroprotective Effects?
There are some unique flavonoids that have antioxidant, anti-inflammatory, and metal chelating activities. Oral absorption of flavonoids is less than 10% and these are heavily metabolized in the liver through methylation and sulphation. Intestinal inflammation further reduces flavonoid absorption, while decreased ability to methylate or sulphate them could lead to “phenol intolerance” presenting as irritability. A new formulation will contain methylated luteolin that has increased absorption and will not require extensive metabolism so that it may enter the brain and reduce inflammation as well as provide protection for mitochondria and neurons.
Theoharis C. Theoharides, PhD, MD, FAAAAI
He is Director of Molecular Immunopharmacology & Drug Discovery Lab, Professor of Pharmacology, Biochemistry and Internal Medicine at Tufts University. He trained at Yale University and has over 290 publications. He showed that mast cells secrete inflammatory mediators that disrupt the gut-blood-brain barriers, thus playing a critical role in brain inflammation and autism. Dr. Theoharides extends his expertise beyond theory into practical options for patients with diseases that have defied treatment to date.
